Oxidized low density lipoprotein (ox-LDL) and its scavenger receptor LOX-1 expression in osteoarthritis

نویسندگان

  • Aspasia Tsezou
  • Theodora Simopoulou
  • Lazaros Poultsides
  • Sokratis Varitimidis
  • Konstantinos N. Malizos
چکیده

Oxidized low density lipoprotein (ox-LDL) and its scavenger receptor LOX-1 expression in osteoarthritis Aspasia Tsezou1,2,3, Theodora Simopoulou1, Lazaros Poultsides4, Sokratis Varitimidis4, Konstantinos N. Malizos3,4 1Department of Cytogenetics and Molecular Genetics, University of Thessalia, Larissa, Greece; 2Department of Biology, University of Thessalia, Larissa, Greece; 3Institute for Biomedical Research and Technology, Larissa, Greece; 4Department of Orthopaedics, University of Thessalia, Larissa, Greece [email protected]

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Lectin-like oxidized low density lipoprotein receptor 1 (LOX-1) expression in human articular chondrocytes.

OBJECTIVE To investigate the involvement of oxidized low density lipoprotein (ox-LDL) and the expression of its receptor lectin-like oxidized low density lipoprotein receptor 1 (LOX-1) in osteoarthritis, by determining the ox-LDL in synovial fluid and the expression of LOX-1 mRNA and protein in osteoarthritic as well as normal cartilage. In addition, the effect of ox-LDL on chondrocyte viabilit...

متن کامل

Ligand specificity of LOX-1, a novel endothelial receptor for oxidized low density lipoprotein.

Endothelial dysfunction, or activation, elicited by oxidized low density lipoprotein (Ox-LDL) and its lipid constituents has been shown to play a key role in the pathogenesis of atherosclerosis. We recently have identified a novel receptor for Ox-LDL-designated lectin-like Ox-LDL receptor (LOX-1) in vascular endothelial cells. To examine ligand specificity of LOX-1, we established CHO cell line...

متن کامل

Dayuan Li and Jawahar L. Mehta Use of Antisense LOX-1 mRNA and Chemical Inhibitors Implications in Apoptosis of Human Coronary Artery Endothelial Cells : Evidence From Upregulation of Endothelial Receptor for Oxidized LDL (LOX-1) by Oxidized LDL

A specific lectinlike endothelial receptor for oxidized low density lipoprotein (LOX-1), distinct from the scavenger receptor in monocytes/macrophages, has been identified and cloned. In this study, we examined the regulation of LOX-1 by oxidized low density lipoprotein (ox-LDL) and determined the role of LOX-1 in ox-LDL–induced apoptosis of cultured human coronary artery endothelial cells (HCA...

متن کامل

Upregulation of endothelial receptor for oxidized LDL (LOX-1) by oxidized LDL and implications in apoptosis of human coronary artery endothelial cells: evidence from use of antisense LOX-1 mRNA and chemical inhibitors.

A specific lectin-like endothelial receptor for oxidized low density lipoprotein (LOX-1), distinct from the scavenger receptor in monocytes/macrophages, has been identified and cloned. In this study, we examined the regulation of LOX-1 by oxidized low density lipoprotein (ox-LDL) and determined the role of LOX-1 in ox-LDL-induced apoptosis of cultured human coronary artery endothelial cells (HC...

متن کامل

Compare the Effect of Eicosapentaenoic Acid and Oxidized Low-Density Lipoprotein on the Expression of CD36 and Peroxisome Proliferator-Activated Receptor Gamma

Background: There is evidence that CD36 promotes foam cell formation through internalizing oxidized LDL (ox-LDL) into macrophages therefore, it plays a key role in pathogenesis of atherosclerosis. In addition, CD36 expression seems to be mediated by nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR-γ). The aim of the present study was to evaluate and compare the effect of ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2002